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Research progress of proteolysis-targeting chimeras in viral hepatitis drug discovery

Proteolysis Targeting Chimera (PROTAC) is an innovative drug discovery strategy that utilizes bifunctional small molecules to bring a target protein (POI) into proximity with an E3 ubiquitin ligase, thereby inducing ubiquitination of the pathogenic protein and its subsequent degradation by the prote...

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Principais autores: Xiaofei Hao, Yanli Wang, Gang Huang, Chaoyang Lin, Peng Zhao, Wubin Zhi, Xiankai Li, Peng Qi, Peng Liu
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-06-01
Serier:Frontiers in Chemistry
Fag:
antiviral drugs
fluorine
hepatitis virus
PROTAC
resistance
Online adgang:https://www.frontiersin.org/articles/10.3389/fchem.2026.1810498/full
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