First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria
ABSTRACT Hutchinson‐Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by a mutation in the LMNA gene, leading to the production of progerin, an aberrant and toxic form of lamin A. Due to its hydrophobic nature, progerin accumulates at the nuclear membrane, disrupting nuclear archite...
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| Huvudupphov: | , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
Wiley
2026-06-01
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| Serie: | Advanced Science |
| Ämnen: | |
| Länkar: | https://doi.org/10.1002/advs.202521608 |
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