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Non-Erythropoietic EPO (EPO-R76E) Protects RPE Cells from Ferroptosis by Modulating the Labile Iron Pool and NRF2-GPX4 Axis

Retinal pigment epithelium (RPE) degeneration remains a formidable challenge in dry age-related macular degeneration (AMD) research, primarily due to the toxic interplay between iron overload and ferroptosis. We investigated whether EPO-R76E, a non-erythropoietic modified variant of erythropoietin,...

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Principais autores: Sundaramoorthy Gopi, George T. Prodanoff, Christopher L. Passaglia, Mark S. Kindy, Vijaykumar Sutariya, Ganesh V. Halade, Alfred S. Lewin, Manas R. Biswal
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-05-01
Serier:Antioxidants
Fag:
age-related macular degeneration (AMD)
retinal pigment epithelium (RPE)
gene therapy
ferroptosis
lipid peroxidation
iron homeostasis
Online adgang:https://www.mdpi.com/2076-3921/15/5/647
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