Non-Erythropoietic EPO (EPO-R76E) Protects RPE Cells from Ferroptosis by Modulating the Labile Iron Pool and NRF2-GPX4 Axis

Retinal pigment epithelium (RPE) degeneration remains a formidable challenge in dry age-related macular degeneration (AMD) research, primarily due to the toxic interplay between iron overload and ferroptosis. We investigated whether EPO-R76E, a non-erythropoietic modified variant of erythropoietin,...

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主要な著者:	Sundaramoorthy Gopi, George T. Prodanoff, Christopher L. Passaglia, Mark S. Kindy, Vijaykumar Sutariya, Ganesh V. Halade, Alfred S. Lewin, Manas R. Biswal
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2026-05-01
シリーズ:	Antioxidants
主題:	age-related macular degeneration (AMD) retinal pigment epithelium (RPE) gene therapy ferroptosis lipid peroxidation iron homeostasis
オンライン･アクセス:	https://www.mdpi.com/2076-3921/15/5/647
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