Small Molecule Antibiotics Inhibit Distinct Stages of Bacterial Outer Membrane Protein Assembly

ABSTRACT Several antibacterial compounds have recently been discovered that potentially inhibit the activity of BamA, an essential subunit of a heterooligomer (the barrel assembly machinery or BAM) that assembles outer membrane proteins (OMPs) in Gram-negative bacteria, but their mode of action is u...

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主要な著者:	Janine H. Peterson, Matthew Thomas Doyle, Harris D. Bernstein
フォーマット:	Artigo
言語:	Inglês
出版事項:	American Society for Microbiology 2022-10-01
シリーズ:	mBio
主題:	antibiotics β signal barrel assembly machinery Gram-negative bacteria membrane proteins outer membrane
オンライン･アクセス:	https://journals.asm.org/doi/10.1128/mbio.02286-22
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