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Small Molecule Antibiotics Inhibit Distinct Stages of Bacterial Outer Membrane Protein Assembly

ABSTRACT Several antibacterial compounds have recently been discovered that potentially inhibit the activity of BamA, an essential subunit of a heterooligomer (the barrel assembly machinery or BAM) that assembles outer membrane proteins (OMPs) in Gram-negative bacteria, but their mode of action is u...

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Principais autores: Janine H. Peterson, Matthew Thomas Doyle, Harris D. Bernstein
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2022-10-01
סדרה:mBio
נושאים:
antibiotics
β signal
barrel assembly machinery
Gram-negative bacteria
membrane proteins
outer membrane
גישה מקוונת:https://journals.asm.org/doi/10.1128/mbio.02286-22
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