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Patients with juvenile idiopathic arthritis have decreased clonal diversity in the CD8+ T cell repertoire response to influenza vaccination

Recurrent exposures to a pathogenic antigen remodel the CD8+ T cell compartment and generate a functional memory repertoire that is polyclonal and complex. At the clonotype level, the response to the conserved influenza antigen, M158–66 has been well characterized in healthy individuals, but not in...

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Kaydedildi:
Asıl Yazarlar: Sara E. Sabbagh, Dipica Haribhai, Jill A. Gershan, James Verbsky, James Nocton, Maryam Yassai, Elena N. Naumova, Erin Hammelev, Mahua Dasgupta, Ke Yan, Jack Gorski, Calvin B. Williams
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2024-05-01
Seri Bilgileri:Frontiers in Immunology
Konular:
CD8 + T cells
T cell repertoire
influenza vaccination
clonotypes
juvenile idiopathic arthritis
clonotype diversity
Online Erişim:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1306490/full
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