Patients with juvenile idiopathic arthritis have decreased clonal diversity in the CD8+ T cell repertoire response to influenza vaccination

Recurrent exposures to a pathogenic antigen remodel the CD8+ T cell compartment and generate a functional memory repertoire that is polyclonal and complex. At the clonotype level, the response to the conserved influenza antigen, M158–66 has been well characterized in healthy individuals, but not in...

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Hlavní autoři:	Sara E. Sabbagh, Dipica Haribhai, Jill A. Gershan, James Verbsky, James Nocton, Maryam Yassai, Elena N. Naumova, Erin Hammelev, Mahua Dasgupta, Ke Yan, Jack Gorski, Calvin B. Williams
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2024-05-01
Edice:	Frontiers in Immunology
Témata:	CD8 + T cells T cell repertoire influenza vaccination clonotypes juvenile idiopathic arthritis clonotype diversity
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1306490/full
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