Benzotriazole derivatives as alternate O-acetylserine sulfhydrylase substrates to impair cysteine biosynthesis in gram-negative bacteria

Summary: Cysteine biosynthetic pathway, unique to bacteria and absent in the human host, represents a relevant reservoir of potential antimicrobial targets. Cysteine, in fact, is involved in redox homeostasis and is prone to the production of reactive oxygen species, and altering its metabolic equil...

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Detalhes bibliográficos

Principais autores:	Stefania Bova, Marialaura Pavone, Costanza Spadini, Nicolò Mezzasalma, Giacomo Quilici, Jole Maria Lucia D’Angelo, Francesca Malagutti, Omar De Bei, Chiara Spaggiari, Luca Ronda, Marco Pieroni, Stefano Bettati, Clotilde Silvia Cabassi, Barbara Campanini, Gabriele Costantino, Marialaura Marchetti, Giannamaria Annunziato
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-11-01
Colecção:	iScience
Assuntos:	chemistry biological sciences
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2589004225020796
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