Refining the structure−activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms

The lack of efficacy of current antibacterials to treat multidrug resistant bacteria poses a life-threatening alarm. In order to develop enhancers of the antibacterial activity, we carried out a medicinal chemistry campaign aiming to develop inhibitors of enzymes that synthesise cysteine and belong...

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Hlavní autoři:	Joana Magalhães, Nina Franko, Giannamaria Annunziato, Marco Pieroni, Roberto Benoni, Anna Nikitjuka, Andrea Mozzarelli, Stefano Bettati, Anna Karawajczyk, Aigars Jirgensons, Barbara Campanini, Gabriele Costantino
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2019-01-01
Edice:	Journal of Enzyme Inhibition and Medicinal Chemistry
Témata:	antibacterials cysteine gram-negatives o-acetylserine sulfhydrylase permeability
On-line přístup:	http://dx.doi.org/10.1080/14756366.2018.1518959
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