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Benzotriazole derivatives as alternate O-acetylserine sulfhydrylase substrates to impair cysteine biosynthesis in gram-negative bacteria

Summary: Cysteine biosynthetic pathway, unique to bacteria and absent in the human host, represents a relevant reservoir of potential antimicrobial targets. Cysteine, in fact, is involved in redox homeostasis and is prone to the production of reactive oxygen species, and altering its metabolic equil...

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Principais autores: Stefania Bova, Marialaura Pavone, Costanza Spadini, Nicolò Mezzasalma, Giacomo Quilici, Jole Maria Lucia D’Angelo, Francesca Malagutti, Omar De Bei, Chiara Spaggiari, Luca Ronda, Marco Pieroni, Stefano Bettati, Clotilde Silvia Cabassi, Barbara Campanini, Gabriele Costantino, Marialaura Marchetti, Giannamaria Annunziato
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-11-01
Serier:iScience
Fag:
chemistry
biological sciences
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589004225020796
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