Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein
Salt-inducible kinase 3 (SIK3) plays a crucial role in various aspects of metabolism. In the course of investigating metabolic defects in Sik3-deficient mice (Sik3-/-), we observed that circadian rhythmicity of the metabolisms was phase-delayed. Sik3-/- mice also exhibited other circadian abnormalit...
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| Principais autores: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications Ltd
2017-12-01
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| Serier: | eLife |
| Fag: | |
| Online adgang: | https://elifesciences.org/articles/24779 |
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