USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock.

Mammalian Cryptochromes, CRY1 and CRY2, function as principal regulators of a transcription-translation-based negative feedback loop underlying the mammalian circadian clockwork. An F-box protein, FBXL3, promotes ubiquitination and degradation of CRYs, while FBXL21, the closest paralog of FBXL3, ubi...

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Principais autores:	Arisa Hirano, Tomoki Nakagawa, Hikari Yoshitane, Masaaki Oyama, Hiroko Kozuka-Hata, Darin Lanjakornsiripan, Yoshitaka Fukada
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2016-01-01
Serija:	PLoS ONE
Online dostop:	https://doi.org/10.1371/journal.pone.0154263
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