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A Mathematical Model to Characterize the Role of Light Adaptation in Mammalian Circadian Clock

In response to a light stimulus, the mammalian circadian clock first dramatically increases the expression of Per1 mRNA, and then drops to a baseline even when light persists. This phenomenon is known as light adaptation, which has been experimentally proven to be related to the CRTC1-SIK1 pathway i...

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Autori principali: Yuzeng Shi, Yu Liu, Ling Yang, Jie Yan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021-12-01
Serie:Frontiers in Molecular Biosciences
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Accesso online:https://www.frontiersin.org/articles/10.3389/fmolb.2021.681696/full
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