A Mathematical Model to Characterize the Role of Light Adaptation in Mammalian Circadian Clock

In response to a light stimulus, the mammalian circadian clock first dramatically increases the expression of Per1 mRNA, and then drops to a baseline even when light persists. This phenomenon is known as light adaptation, which has been experimentally proven to be related to the CRTC1-SIK1 pathway i...

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מידע ביבליוגרפי

Principais autores:	Yuzeng Shi, Yu Liu, Ling Yang, Jie Yan
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2021-12-01
סדרה:	Frontiers in Molecular Biosciences
נושאים:	circadian clock CRTC1-SIK1 pathway light adaptation phase robustness singularity refractoriness
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fmolb.2021.681696/full
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