Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein

Salt-inducible kinase 3 (SIK3) plays a crucial role in various aspects of metabolism. In the course of investigating metabolic defects in Sik3-deficient mice (Sik3-/-), we observed that circadian rhythmicity of the metabolisms was phase-delayed. Sik3-/- mice also exhibited other circadian abnormalit...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Naoto Hayasaka, Arisa Hirano, Yuka Miyoshi, Isao T Tokuda, Hikari Yoshitane, Junichiro Matsuda, Yoshitaka Fukada
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	eLife Sciences Publications Ltd 2017-12-01
Edice:	eLife
Témata:	SIK3 knockout circadian rhythm PER2 degradation salt-inducible kinase
On-line přístup:	https://elifesciences.org/articles/24779
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!