First validated liquid chromatography–tandem mass spectrometry method for simultaneous quantification of propranolol and 4-hydroxypropranolol in pig plasma and dried blood spots and its application to a pharmacokinetic study

Background and Aim: Propranolol is a widely used non-selective beta-adrenergic blocker in human medicine, with well-characterized pharmacokinetics (PK) in humans but virtually no data available for pigs, a species of growing biomedical relevance. Furthermore, no validated bioanalytical methods exist...

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Hauptverfasser:	Anisa Bardhi, Domenico Ventrella, Alberto Elmi, Ronette Gehring, Davide Martelli, Ilaria Troisio, Maria Laura Bacci, Andrea Barbarossa
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Veterinary World 2026-01-01
Schriftenreihe:	Veterinary World
Schlagworte:	4-hydroxypropranolol beta-blocker dried blood spots liquid chromatography–tandem mass spectrometry microsampling pharmacokinetics pigs propranolol
Online-Zugang:	https://veterinaryworld.org/Vol.19/January-2026/2.pdf
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