The novel BET‐CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild‐type prostate cancer

Abstract CULLIN3‐based E3 ubiquitin ligase substrate‐binding adaptor gene SPOP is frequently mutated in prostate cancer (PCa). PCa harboring SPOP hotspot mutants (e.g., F133V) are resistant to BET inhibitors because of aberrant elevation of BET proteins. Here, we identified a previously unrecognized...

全面介紹

書目詳細資料

Principais autores:	Yuqian Yan, Jian Ma, Dejie Wang, Dong Lin, Xiaodong Pang, Shangqian Wang, Yu Zhao, Lei Shi, Hui Xue, Yunqian Pan, Jun Zhang, Claes Wahlestedt, Francis J Giles, Yu Chen, Martin E Gleave, Collin C Collins, Dingwei Ye, Yuzhuo Wang, Haojie Huang
格式:	Artigo
語言:	Inglês
出版:	Springer Nature 2019-09-01
叢編:	EMBO Molecular Medicine
主題:	BRD4 CBP/p300 NEO2734 prostate cancer SPOP
在線閱讀:	https://doi.org/10.15252/emmm.201910659
標簽:	添加標簽 沒有標簽, 成為第一個標記此記錄!