The novel BET‐CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild‐type prostate cancer

Abstract CULLIN3‐based E3 ubiquitin ligase substrate‐binding adaptor gene SPOP is frequently mutated in prostate cancer (PCa). PCa harboring SPOP hotspot mutants (e.g., F133V) are resistant to BET inhibitors because of aberrant elevation of BET proteins. Here, we identified a previously unrecognized...

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Bibliografische Detailangaben

Hauptverfasser:	Yuqian Yan, Jian Ma, Dejie Wang, Dong Lin, Xiaodong Pang, Shangqian Wang, Yu Zhao, Lei Shi, Hui Xue, Yunqian Pan, Jun Zhang, Claes Wahlestedt, Francis J Giles, Yu Chen, Martin E Gleave, Collin C Collins, Dingwei Ye, Yuzhuo Wang, Haojie Huang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Springer Nature 2019-09-01
Schriftenreihe:	EMBO Molecular Medicine
Schlagworte:	BRD4 CBP/p300 NEO2734 prostate cancer SPOP
Online-Zugang:	https://doi.org/10.15252/emmm.201910659
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