The novel BET‐CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild‐type prostate cancer

Abstract CULLIN3‐based E3 ubiquitin ligase substrate‐binding adaptor gene SPOP is frequently mutated in prostate cancer (PCa). PCa harboring SPOP hotspot mutants (e.g., F133V) are resistant to BET inhibitors because of aberrant elevation of BET proteins. Here, we identified a previously unrecognized...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Yuqian Yan, Jian Ma, Dejie Wang, Dong Lin, Xiaodong Pang, Shangqian Wang, Yu Zhao, Lei Shi, Hui Xue, Yunqian Pan, Jun Zhang, Claes Wahlestedt, Francis J Giles, Yu Chen, Martin E Gleave, Collin C Collins, Dingwei Ye, Yuzhuo Wang, Haojie Huang
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Springer Nature 2019-09-01
Sarja:	EMBO Molecular Medicine
Aiheet:	BRD4 CBP/p300 NEO2734 prostate cancer SPOP
Linkit:	https://doi.org/10.15252/emmm.201910659
Tagit:	Lisää tagi Ei tageja, Lisää ensimmäinen tagi!