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Esculetin Provides Neuroprotection against Mutant Huntingtin-Induced Toxicity in Huntington’s Disease Models

Huntington’s disease (HD) is a neurodegenerative disorder caused by an abnormal CAG trinucleotide repeat expansion within exon 1 of the huntingtin (HTT) gene. This mutation leads to the production of mutant HTT (mHTT) protein which triggers neuronal death through several mechanisms. Here, we investi...

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Principais autores: Letizia Pruccoli, Carlo Breda, Gabriella Teti, Mirella Falconi, Flaviano Giorgini, Andrea Tarozzi
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2021-10-01
coleção:Pharmaceuticals
Assuntos:
Huntington’s disease
huntingtin
mitochondrial dysfunction
oxidative stress
neuroprotection
esculetin
Acesso em linha:https://www.mdpi.com/1424-8247/14/10/1044
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