Astrocytes contribute to toll-like receptor 2-mediated neurodegeneration and alpha-synuclein pathology in a human midbrain Parkinson’s model

Abstract Background Parkinson’s disease (PD) is characterised by degeneration of ventral midbrain dopaminergic (DA) neurons and abnormal deposition of α-synuclein (α-syn) in neurons. Activation of the innate immune pathogen recognition receptor toll-like receptor 2 (TLR2) is associated with exacerba...

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Bibliografiset tiedot

Päätekijät:	Fiona Weiss, Laura Hughes, Yuhong Fu, Cedric Bardy, Glenda M. Halliday, Nicolas Dzamko
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	BMC 2024-12-01
Sarja:	Translational Neurodegeneration
Aiheet:	Parkinson’s disease Toll-like receptor 2 Alpha-synuclein Astrocyte Lysosome
Linkit:	https://doi.org/10.1186/s40035-024-00448-3
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