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High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease

Abstract Alpha-synuclein seed amplification assays (αSyn-SAAs) are promising diagnostic tools for Parkinson’s disease (PD) and related synucleinopathies. They enable detection of seeding-competent alpha-synuclein aggregates in living patients and have shown high diagnostic accuracy in several PD and...

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Principais autores: Marco J. Russo, Christina D. Orru, Luis Concha-Marambio, Simone Giaisi, Bradley R. Groveman, Carly M. Farris, Bret Holguin, Andrew G. Hughson, David-Erick LaFontant, Chelsea Caspell-Garcia, Christopher S. Coffey, Jennifer Mollon, Samantha J. Hutten, Kalpana Merchant, Roland G. Heym, Claudio Soto, Byron Caughey, Un Jung Kang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2021-11-01
Serier:Acta Neuropathologica Communications
Fag:
Seed amplification assay
Alpha-synuclein
Parkinson’s disease
RT-QuIC
PMCA
Synucleinopathy
Online adgang:https://doi.org/10.1186/s40478-021-01282-8
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