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Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease

Abstract Currently, there is a need for diagnostic markers in Lewy body disorders (LBD). α-synuclein (αSyn) RT-QuIC has emerged as a promising assay to detect misfolded αSyn in clinically or neuropathologically established patients with various synucleinopathies. In this study, αSyn RT-QuIC was used...

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Principais autores: Sara Hall, Christina D. Orrù, Geidy E. Serrano, Douglas Galasko, Andrew G. Hughson, Bradley R. Groveman, Charles H. Adler, Thomas G. Beach, Byron Caughey, Oskar Hansson
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-06-01
coleção:Acta Neuropathologica Communications
Assuntos:
Cerebrospinal fluid
Biomarkers
Parkinson disease
Dementia with Lewy bodies
Lewy body dementia
Diagnosis
Acesso em linha:https://doi.org/10.1186/s40478-022-01388-7
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