Development, initial validation, and application of a visual read method for [18F]MK‐6240 tau PET

Abstract Background The positron emission tomography (PET) radiotracer [18F]MK‐6240 exhibits high specificity for neurofibrillary tangles (NFTs) of tau protein in Alzheimer's disease (AD), high sensitivity to medial temporal and neocortical NFTs, and low within‐brain background. Objectives were to d...

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Hlavní autoři:	Joanna L. Shuping, Dawn C. Matthews, Katarzyna Adamczuk, David Scott, Christopher C. Rowe, William C. Kreisl, Sterling C. Johnson, Ana S. Lukic, Keith A. Johnson, Pedro Rosa‐Neto, Randolph D. Andrews, Koen Van Laere, Lindsay Cordes, Larry Ward, Claire L. Wilde, Jerome Barakos, Derk D. Purcell, Davangere P. Devanand, Yaakov Stern, Jose A. Luchsinger, Cyrille Sur, Julie C. Price, Adam M. Brickman, William E. Klunk, Adam L. Boxer, Sulantha S. Mathotaarachchi, Patrick J. Lao, Jeffrey L. Evelhoch
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2023-01-01
Edice:	Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Témata:	Alzheimer's disease florquinitau neurofibrillary tangles positron emission tomography tau tracer
On-line přístup:	https://doi.org/10.1002/trc2.12372
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