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Development, initial validation, and application of a visual read method for [18F]MK‐6240 tau PET

Abstract Background The positron emission tomography (PET) radiotracer [18F]MK‐6240 exhibits high specificity for neurofibrillary tangles (NFTs) of tau protein in Alzheimer's disease (AD), high sensitivity to medial temporal and neocortical NFTs, and low within‐brain background. Objectives were to d...

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Asıl Yazarlar: Joanna L. Shuping, Dawn C. Matthews, Katarzyna Adamczuk, David Scott, Christopher C. Rowe, William C. Kreisl, Sterling C. Johnson, Ana S. Lukic, Keith A. Johnson, Pedro Rosa‐Neto, Randolph D. Andrews, Koen Van Laere, Lindsay Cordes, Larry Ward, Claire L. Wilde, Jerome Barakos, Derk D. Purcell, Davangere P. Devanand, Yaakov Stern, Jose A. Luchsinger, Cyrille Sur, Julie C. Price, Adam M. Brickman, William E. Klunk, Adam L. Boxer, Sulantha S. Mathotaarachchi, Patrick J. Lao, Jeffrey L. Evelhoch
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Wiley 2023-01-01
Seri Bilgileri:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Konular:
Alzheimer's disease
florquinitau
neurofibrillary tangles
positron emission tomography
tau
tracer
Online Erişim:https://doi.org/10.1002/trc2.12372
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