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New link between the RNA polymerase II-CTD and replication stress

Conflicts between transcription and replication are a major source of replication stress. Our recent findings show that proper dephosphorylation of Serine 5 in the carboxy-terminal domain (CTD) of DNA-directed RNA polymerase II subunit RPB1 is needed to prevent such conflicts in human cells.

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Autori principali: Helga B. Landsverk, Lise E. Sandquist, Lilli T. E. Bay, Randi G. Syljuåsen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis Group 2021-05-01
Serie:Molecular & Cellular Oncology
Soggetti:
replication stress
transcription-replication conflicts
pp1 phosphatase
rna polymerase ii
pp1 nuclear targeting subunit (pnuts)
carboxy-terminal domain (ctd)
wd repeat-containing protein 82 (wdr82)
Accesso online:http://dx.doi.org/10.1080/23723556.2021.1910008
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