Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate

Acid-sensing ion channels (ASICs) are neuronal Na+ channels that are activated by a drop in pH. Their established physiological and pathological roles, involving fear behaviors, learning, pain sensation, and neurodegeneration after stroke, make them promising targets for future drugs. Currently, the...

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Detalhes bibliográficos

Principais autores:	Sabrina Vullo, Nicolas Ambrosio, Jan P Kucera, Olivier Bignucolo, Stephan Kellenberger
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2021-03-01
coleção:	eLife
Assuntos:	conformational change ion channel voltage-clamp fluorometry molecular dynamics kinetic model
Acesso em linha:	https://elifesciences.org/articles/66488
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