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Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate

Acid-sensing ion channels (ASICs) are neuronal Na+ channels that are activated by a drop in pH. Their established physiological and pathological roles, involving fear behaviors, learning, pain sensation, and neurodegeneration after stroke, make them promising targets for future drugs. Currently, the...

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Principais autores: Sabrina Vullo, Nicolas Ambrosio, Jan P Kucera, Olivier Bignucolo, Stephan Kellenberger
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2021-03-01
Serier:eLife
Fag:
conformational change
ion channel
voltage-clamp fluorometry
molecular dynamics
kinetic model
Online adgang:https://elifesciences.org/articles/66488
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