Genetic polymorphisms of GSTP1 and XRCC1: prediction of clinical outcome of platinum-based chemotherapy in advanced non-small cell lung cancer (NSCLC) patients

PRINCIPLES: Platinum agents cause DNA cross-linking and oxidative damage. Genetic polymorphisms of GSTP1 and XRCC1 involved in glutathione metabolic and DNA repair pathways may explain inter individual differences in chemosensitivity and clinical outcome in NSCLC patients treated with platinum-...

Disgrifiad llawn

Manylion Llyfryddiaeth

Prif Awduron:	F zhou, Z yu, T jiang, H lv, R yao, J liang
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	SMW supporting association (Trägerverein Swiss Medical Weekly SMW) 2011-10-01
Cyfres:	Swiss Medical Weekly
Pynciau:	carcinoma genetic polymorphisms glutathione S-transferase pi non-small-cell lung platinum X-ray repair cross complementing protein 1
Mynediad Ar-lein:	https://www.smw.ch/index.php/smw/article/view/1367
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!