Genetic polymorphisms of GSTP1 and XRCC1: prediction of clinical outcome of platinum-based chemotherapy in advanced non-small cell lung cancer (NSCLC) patients

PRINCIPLES: Platinum agents cause DNA cross-linking and oxidative damage. Genetic polymorphisms of GSTP1 and XRCC1 involved in glutathione metabolic and DNA repair pathways may explain inter individual differences in chemosensitivity and clinical outcome in NSCLC patients treated with platinum-...

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Principais autores:	F zhou, Z yu, T jiang, H lv, R yao, J liang
Format:	Artigo
Jezik:	Inglês
Izdano:	SMW supporting association (Trägerverein Swiss Medical Weekly SMW) 2011-10-01
Serija:	Swiss Medical Weekly
Teme:	carcinoma genetic polymorphisms glutathione S-transferase pi non-small-cell lung platinum X-ray repair cross complementing protein 1
Online dostop:	https://www.smw.ch/index.php/smw/article/view/1367
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