Predicting favorable landing pads for targeted integrations in Chinese hamster ovary cell lines by learning stability characteristics from random transgene integrations

Chinese Hamster Ovary (CHO) cell lines are considered to be the preferred platform for the production of biotherapeutics, but issues related to expression instability remain unresolved. In this study, we investigated potential causes for an unstable phenotype by comparing cell lines that express sta...

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Автори:	Heena Dhiman, Marguerite Campbell, Michael Melcher, Kevin D. Smith, Nicole Borth
Формат:	Artigo
Мова:	Inglês
Опубліковано:	American Association for the Advancement of Science (AAAS) 2020-01-01
Серія:	Computational and Structural Biotechnology Journal
Предмети:	Genomics Transcriptomics Integration sites Stable transgene expression Chinese hamster ovary cells
Онлайн доступ:	http://www.sciencedirect.com/science/article/pii/S200103702030475X
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