Predicting favorable landing pads for targeted integrations in Chinese hamster ovary cell lines by learning stability characteristics from random transgene integrations

Chinese Hamster Ovary (CHO) cell lines are considered to be the preferred platform for the production of biotherapeutics, but issues related to expression instability remain unresolved. In this study, we investigated potential causes for an unstable phenotype by comparing cell lines that express sta...

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Detalhes bibliográficos

Principais autores:	Heena Dhiman, Marguerite Campbell, Michael Melcher, Kevin D. Smith, Nicole Borth
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Association for the Advancement of Science (AAAS) 2020-01-01
coleção:	Computational and Structural Biotechnology Journal
Assuntos:	Genomics Transcriptomics Integration sites Stable transgene expression Chinese hamster ovary cells
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S200103702030475X
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