CRISPR‐Cas9–Mediated Genome Editing Confirms EPDR1 as an Effector Gene at the BMD GWAS‐Implicated ‘STARD3NL’ Locus

ABSTRACT Genome‐wide–association studies (GWASs) have discovered genetic signals robustly associated with BMD, but typically not the precise localization of effector genes. By intersecting genome‐wide promoter‐focused Capture C and assay for transposase‐accessible chromatin using sequencing (ATAC‐se...

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Detalhes bibliográficos

Principais autores:	James A Pippin, Alessandra Chesi, Yadav Wagley, Chun Su, Matthew C Pahl, Kenyaita M Hodge, Matthew E Johnson, Andrew D Wells, Kurt D Hankenson, Struan F A Grant
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2021-09-01
Colecção:	JBMR Plus
Assuntos:	BONE MINERAL DENSITY (BMD) CHROMATIN CAPTURE CRISPR OSTEOBLAST DIFFERENTIATION OSTEOBLAST PROGENITOR
Acesso em linha:	https://doi.org/10.1002/jbm4.10531
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