Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells

T cells are a major cell type involved in systemic lupus erythematosus (SLE). Here, the authors use promoter capture-C and ATAC-seq in human follicular T helper cells to identify SLE genes distant from GWAS loci (via 3D interaction) and validate the function of key regulatory elements and genes in v...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Chun Su, Matthew E. Johnson, Annabel Torres, Rajan M. Thomas, Elisabetta Manduchi, Prabhat Sharma, Parul Mehra, Carole Le Coz, Michelle E. Leonard, Sumei Lu, Kenyaita M. Hodge, Alessandra Chesi, James Pippin, Neil Romberg, Struan F. A. Grant, Andrew D. Wells
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2020-07-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-020-17089-5
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!