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Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism

Objective: Hepatic triacylglycerol accumulation and insulin resistance are key features of NAFLD. However, NAFLD development and progression are rather triggered by the aberrant generation of lipid metabolites and signaling molecules including diacylglycerol (DAG) and lysophosphatidylcholine (lysoPC...

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Principais autores: Gabriel Chalhoub, Alina Jamnik, Laura Pajed, Stephanie Kolleritsch, Victoria Hois, Antonia Bagaric, Dominik Prem, Anna Tilp, Dagmar Kolb, Heimo Wolinski, Ulrike Taschler, Thomas Züllig, Gerald N. Rechberger, Claudia Fuchs, Michael Trauner, Gabriele Schoiswohl, Guenter Haemmerle
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2023-06-01
coleção:Molecular Metabolism
Assuntos:
NAFLD
Obesity
Carboxylesterase 2
Lipid signaling
Insulin resistance
DAG accumulation
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2212877823000595
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