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Nardilysin in adipocyte regulates insulin sensitivity via HIF1α and PPARγ

Abstract Obesity is a critical global health issue and a major risk factor for type 2 diabetes mellitus (T2DM). However, molecular mechanism by which obesity leads to T2DM has not been fully elucidated. Here, we investigated the role of adipocyte nardilysin (NRDC) in insulin sensitivity using adipoc...

Deskribapen osoa

Gorde:
Egile Nagusiak: Shintaro Matsuda, Mikiko Ohno, Kiyoto Nishi, Shinya Ikeda, Hirotaka Iwasaki, Taiki Eifuku, Yoshinori Hiraoka, Takeshi Kimura, Koh Ono, Eiichiro Nishi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Portfolio 2025-10-01
Saila:Scientific Reports
Gaiak:
Nardilysin (NRDC)
Adipocyte
Insulin sensitivity
Oxygen consumption
HIF1α
PPARγ
Sarrera elektronikoa:https://doi.org/10.1038/s41598-025-21276-z
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