Nardilysin in adipocyte regulates insulin sensitivity via HIF1α and PPARγ

Abstract Obesity is a critical global health issue and a major risk factor for type 2 diabetes mellitus (T2DM). However, molecular mechanism by which obesity leads to T2DM has not been fully elucidated. Here, we investigated the role of adipocyte nardilysin (NRDC) in insulin sensitivity using adipoc...

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Autors principals:	Shintaro Matsuda, Mikiko Ohno, Kiyoto Nishi, Shinya Ikeda, Hirotaka Iwasaki, Taiki Eifuku, Yoshinori Hiraoka, Takeshi Kimura, Koh Ono, Eiichiro Nishi
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-10-01
Col·lecció:	Scientific Reports
Matèries:	Nardilysin (NRDC) Adipocyte Insulin sensitivity Oxygen consumption HIF1α PPARγ
Accés en línia:	https://doi.org/10.1038/s41598-025-21276-z
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