Association of MTHFD1G1958A, MTHFD1T401C, and DHFR-19bp variants with sperm criteria and unexplained male infertility: a case–control study on Algerian population

Abstract Background Methylenetetrahydrofolate dehydrogenase (MTHFD1) and Dihydrofolate reductase (DHFR) are pivotal enzymes in the folate metabolic pathway, playing essential roles in DNA synthesis, repair, and methylation processes critical for spermatogenesis. Numerous studies have implicated gene...

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Detalhes bibliográficos

Principais autores:	Nour El Houda Bousnane, Abed Alkarem Abu Alhaija, Housna Labed, Anissa Fizazi, Chahinez Amira Dahmani, May Fouad Sadiq
Formato:	Artigo
Idioma:	Inglês
Publicado em:	SpringerOpen 2025-04-01
coleção:	Middle East Fertility Society Journal
Assuntos:	Male infertility MTHFD1C401T MTHFD1G1958A DHFR-19bp Semen criteria Folate metabolism
Acesso em linha:	https://doi.org/10.1186/s43043-025-00223-y
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