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Association of MTHFD1G1958A, MTHFD1T401C, and DHFR-19bp variants with sperm criteria and unexplained male infertility: a case–control study on Algerian population

Abstract Background Methylenetetrahydrofolate dehydrogenase (MTHFD1) and Dihydrofolate reductase (DHFR) are pivotal enzymes in the folate metabolic pathway, playing essential roles in DNA synthesis, repair, and methylation processes critical for spermatogenesis. Numerous studies have implicated gene...

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Principais autores: Nour El Houda Bousnane, Abed Alkarem Abu Alhaija, Housna Labed, Anissa Fizazi, Chahinez Amira Dahmani, May Fouad Sadiq
פורמט: Artigo
שפה:Inglês
יצא לאור: SpringerOpen 2025-04-01
סדרה:Middle East Fertility Society Journal
נושאים:
Male infertility
MTHFD1C401T
MTHFD1G1958A
DHFR-19bp
Semen criteria
Folate metabolism
גישה מקוונת:https://doi.org/10.1186/s43043-025-00223-y
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