Association of MTHFD1G1958A, MTHFD1T401C, and DHFR-19bp variants with sperm criteria and unexplained male infertility: a case–control study on Algerian population

Abstract Background Methylenetetrahydrofolate dehydrogenase (MTHFD1) and Dihydrofolate reductase (DHFR) are pivotal enzymes in the folate metabolic pathway, playing essential roles in DNA synthesis, repair, and methylation processes critical for spermatogenesis. Numerous studies have implicated gene...

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Hauptverfasser:	Nour El Houda Bousnane, Abed Alkarem Abu Alhaija, Housna Labed, Anissa Fizazi, Chahinez Amira Dahmani, May Fouad Sadiq
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	SpringerOpen 2025-04-01
Schriftenreihe:	Middle East Fertility Society Journal
Schlagworte:	Male infertility MTHFD1C401T MTHFD1G1958A DHFR-19bp Semen criteria Folate metabolism
Online-Zugang:	https://doi.org/10.1186/s43043-025-00223-y
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