The Two Sweet Sides of Janus Lectin Drive Crosslinking of Liposomes to Cancer Cells and Material Uptake

A chimeric, bispecific Janus lectin has recently been engineered with different, rationally oriented recognition sites. It can bind simultaneously to sialylated and fucosylated glycoconjugates. Because of its multivalent architecture, this lectin reaches nanomolar avidities for sialic acid and fucos...

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Auteurs principaux:	Lina Siukstaite, Francesca Rosato, Anna Mitrovic, Peter Fritz Müller, Katharina Kraus, Simona Notova, Anne Imberty, Winfried Römer
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2021-11-01
Collection:	Toxins
Sujets:	chimeric carbohydrate protein engineering hypersialylation giant unilamellar vesicles drug delivery cancer cell targeting
Accès en ligne:	https://www.mdpi.com/2072-6651/13/11/792
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