Dimeric Lectin Chimeras as Novel Candidates for Gb3-Mediated Transcytotic Drug Delivery through Cellular Barriers

Receptor-mediated transcytosis is an elegant and promising strategy for drug delivery across biological barriers. Here, we describe a novel ligand–receptor pair based on a dimeric, engineered derivative of the <i>Pseudomonas aeruginosa</i> lectin LecA, here termed Di-LecA, and the host cell glycosph...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Maokai Xu, Maria Antonova, Pavel Salavei, Katharina Illek, Ana Valeria Meléndez, Ramin Omidvar, Roland Thuenauer, Olga Makshakova, Winfried Römer
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	MDPI AG 2023-01-01
Цуврал:	Pharmaceutics
Нөхцлүүд:	Gb3-binding lectin glycosphingolipid transcytosis drug carrier protein engineering protein structure
Онлайн хандалт:	https://www.mdpi.com/1999-4923/15/1/225
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!