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Roles of conserved active site residues in the IscS cysteine desulfurase reaction

Escherichia coli cysteine desulfurase (CD), IscS, modifies basal metabolism by transferring sulphur (S) from L-cysteine to numerous cellular pathways, whereas NFS1, a human CD, is active only in the formation of the [Acp]2:[ISD11]2:[NFS1]2 complex. Despite the accumulation of red-coloured IscS in E....

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Principais autores: Yilin Pang, Jing Wang, Xueping Gao, Mengyao Jiang, Lifei Zhu, Feng Liang, Mengxiang Liang, Xiaolin Wu, Xianxian Xu, Xiaojun Ren, Ting Xie, Wu Wang, Qianqian Sun, Xiaojun Xiong, Jianxin Lyu, Jianghui Li, Guoqiang Tan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-02-01
coleção:Frontiers in Microbiology
Assuntos:
cysteine desulfurase
pyridoxal 5′-phosphate
active site residues
Cys-aldimine
Cys-ketimine
antimicrobial resistance
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1084205/full
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