Proton Nuclear Magnetic Resonance Metabolomics Corroborates Serine Hydroxymethyltransferase as the Primary Target of 2-Aminoacrylate in a <italic toggle="yes">ridA</italic> Mutant of <named-content content-type="genus-species">Salmonella enterica</named-content>
ABSTRACT The reactive intermediate deaminase RidA (EC 3.5.99.10) is conserved across all domains of life and deaminates reactive enamine species. When Salmonella enterica ridA mutants are grown in minimal medium, 2-aminoacrylate (2AA) accumulates, damages several pyridoxal 5′-phosphate (PLP)-depende...
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| Principais autores: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2020-04-01
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| Serija: | mSystems |
| Teme: | |
| Online dostop: | https://journals.asm.org/doi/10.1128/mSystems.00843-19 |
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