Polypeptide-engineered lipid nanoparticles for mRNA delivery with limited immunogenicity

Abstract Lipid nanoparticles (LNPs) have shown great potential for mRNA delivery, with polyethylene glycol (PEG) lipids playing a critical role in modulating particle size, stability and biodistribution. However, most PEGylated LNPs induce anti-PEG antibodies, leading to hypersensitivity and diminis...

Descripción completa

Detalles Bibliográficos

Autores principales:	Jin-Yue Zeng, Yue Zhang, Gui Zhao, Brandon Yi Loong Seow, Nithiyaa Bala Krishnan, Jin Hao Goh, Yi Yan Yang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2026-05-01
Colección:	Nature Communications
Acceso en línea:	https://doi.org/10.1038/s41467-026-73698-6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!