Exatecan Antibody Drug Conjugates Based on a Hydrophilic Polysarcosine Drug-Linker Platform

We herein report the development and evaluation of a novel HER2-targeting antibody–drug conjugate (ADC) based on the topoisomerase I inhibitor payload exatecan, using our hydrophilic monodisperse polysarcosine (PSAR) drug-linker platform (PSARlink). In vitro and in vivo experiments were conducted in...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Louise Conilh, Guy Fournet, Eric Fourmaux, Angélique Murcia, Eva-Laure Matera, Benoît Joseph, Charles Dumontet, Warren Viricel
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	MDPI AG 2021-03-01
Цуврал:	Pharmaceuticals
Нөхцлүүд:	antibody–drug conjugates polysarcosine deruxtecan topoisomerase I inhibitor camptothecin
Онлайн хандалт:	https://www.mdpi.com/1424-8247/14/3/247
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!