Polypeptide-engineered lipid nanoparticles for mRNA delivery with limited immunogenicity
Abstract Lipid nanoparticles (LNPs) have shown great potential for mRNA delivery, with polyethylene glycol (PEG) lipids playing a critical role in modulating particle size, stability and biodistribution. However, most PEGylated LNPs induce anti-PEG antibodies, leading to hypersensitivity and diminis...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Portfolio
2026-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-026-73698-6 |
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