AICAR and nicotinamide treatment synergistically augment the proliferation and attenuate senescence-associated changes in mesenchymal stromal cells

Abstract Background Mesenchymal stromal cell (MSC) stemness capacity diminishes over prolonged in vitro culture, which negatively affects their application in regenerative medicine. To slow down the senescence of MSCs, here, we have evaluated the in vitro effects of 5-aminoimidazole-4-carboxamide ri...

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Principais autores:	Mohammadhossein Khorraminejad-Shirazi, Mahsa Sani, Tahereh Talaei-Khozani, Mohammadreza Dorvash, Malihe Mirzaei, Mohammad Ali Faghihi, Ahmad Monabati, Armin Attar
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2020-02-01
Serija:	Stem Cell Research & Therapy
Teme:	mTOR AMPK SIRT1 Autophagy Senescence AICAR
Online dostop:	https://doi.org/10.1186/s13287-020-1565-6
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