AICAR and nicotinamide treatment synergistically augment the proliferation and attenuate senescence-associated changes in mesenchymal stromal cells

Abstract Background Mesenchymal stromal cell (MSC) stemness capacity diminishes over prolonged in vitro culture, which negatively affects their application in regenerative medicine. To slow down the senescence of MSCs, here, we have evaluated the in vitro effects of 5-aminoimidazole-4-carboxamide ri...

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Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Mohammadhossein Khorraminejad-Shirazi, Mahsa Sani, Tahereh Talaei-Khozani, Mohammadreza Dorvash, Malihe Mirzaei, Mohammad Ali Faghihi, Ahmad Monabati, Armin Attar
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2020-02-01
Rangatū:	Stem Cell Research & Therapy
Ngā marau:	mTOR AMPK SIRT1 Autophagy Senescence AICAR
Urunga tuihono:	https://doi.org/10.1186/s13287-020-1565-6
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!